You will be logged off in  seconds due to inactivity. Click here to continue using this web page.

Choose your region, country/territory, and preferred language

Phosphorothioate Bonds Modifications

Phosphorothioate Bond

The phosphorothioate (PS) bond substitutes a sulfur atom for a non-bridging oxygen in the phosphate backbone of an oligo. This modification renders the internucleotide linkage resistant to nuclease degradation. Phosphorothioate bonds can be introduced between the last 3-5 nucleotides at the 5'- or 3'-end of the oligo to inhibit exonuclease degradation. Including phosphorothioate bonds throughout the entire oligo will help reduce attack by endonucleases as well.

Phosphorothioate Bond Entry
Bond NameSymbolExample
Phosphorothioated DNA bases _* e.g. A*
Phosphorothioated RNA bases r_* e.g. rA*
Phosphorothioated 2' O-methyl bases m_* e.g. mA*
Phosphorothioated Affinity Plus (locked nucleic acid) bases +_* e.g. +A*
Pricing Details (price per bond)
Product Pricing Order
100 nmole DNA Oligo$7.00 SGDAdd to Order
250 nmole DNA Oligo$7.00 SGDAdd to Order
1 umole DNA Oligo$9.50 SGDAdd to Order
2 µmole DNA Oligo$17.50 SGDAdd to Order
5 umole DNA Oligo$38.00 SGDAdd to Order
10 umole DNA Oligo$57.00 SGDAdd to Order
100 nmole RNA Oligo$7.00 SGDAdd to Order
250 nmole RNA Oligo$7.00 SGDAdd to Order
1 umole RNA Oligo$9.50 SGDAdd to Order
5 umole RNA Oligo$38.00 SGDAdd to Order
10 umole RNA Oligo$57.00 SGDAdd to Order
100 nmole DNA Plate Oligo$7.00 SGDAdd to Order
250 nmole DNA Plate Oligo$7.00 SGDAdd to Order
1 umole DNA Plate Oligo$9.50 SGDAdd to Order
4 nmole Ultramer™ DNA Oligo$7.00 SGDAdd to Order
20 nmole Ultramer™ DNA Oligo$7.00 SGDAdd to Order