Archer™ VARIANTPlex™ Hereditary Cancer panel

Discover important alterations for inherited disease research

Identify SNVs, indels, CNVs and intragenic structural variants in 55 genes relevant for breast, colorectal, endometrial, melanoma, gastric, pancreatic and other inherited cancer research.

Detect confidently with Archer NGS Panels for DNA.

Talk to a technical sales expert

Learn how the VARIANTPlex Hereditary Cancer panel can identify key genomic alterations for your research.

Request a consultation

Product details

Panel specifications

Specifications
Targeted genes 55
Genomic alterations SNVs, indels, CNVs, and intragenic structural variants
Input nucleic acid required* ≥10 ng
Recommended number of reads 1.5 M for germline applications
8 M for somatic applications
Hands-on time <2.5 hours
Total library prep time 1.5 days
Platform compatibility Illumina®
Reagent format Lyophilized or liquid
Supported sample types Whole blood, saliva, FFPE

* Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50 ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200 ng is recommended.

Gene targets

APC
ATM
AXIN2
BAP1
BARD1
BMPR1A
BRCA1
BRCA2
BRIP1
CDH1
CDK4
CDKN2A
CHEK2
CTNNA1
DICER1
EGFR
EPCAM
FH
FLCN
GREM1
HOXB13
KIT
MAX
MBD4
MEN1
MET
MLH1
MSH2
MSH3
MSH6
MUTYH
NF1
NTHL1
PALB2
PDGFRA
PMS2
POLD1
POLE
PTEN
RAD51C
RAD51D
RET
SDHA
SDHAF2
SDHB
SDHC
SDHD
SMAD4
SMARCA4
STK11
TMEM127
TP53
TSC1
TSC2
VHL

Interested in adding a few genes to these panels?

Customize this NGS panel by adding any of our functionally-tested designs or create a new panel that fits your exact requirements with Assay Marketplace.

Customize today

Benefits

  • Integrated Solution—Anchored Multiplex PCR (AMP™) chemistry paired with purpose build analysis software enables you to detect complex variants on a single solutions platform.
  • Customize content—Use Assay Marketplace to modify any panel to fit your lab’s needs or start from scratch to keep up with the pace of discovery.
  • Scale easily—Liquid reagents enable automated liquid handling workflows for high volume research labs, while Anchored Multiplex PCR (AMP™) chemistry fuels reliable performance at scale.

Ready to start?

Talk with our technical sales team. Learn how the VARIANTPlex Hereditary Cancer panel can identify key genomic alterations for your research.

Request a consultation

Frequently asked questions

Related products

RUO24-3253_001