Are there specific recommendations for low-complexity samples when using the xGen DNA Library Prep EZ and EZ UNI Kits?

The xGen DNA Library Prep EZ and EZ UNI Kits work well with human genomic DNA and bacterial strains, but they can also be used with low-complexity samples, such as small viral genomes. However, these low-complexity samples may become over-fragmented if standard parameters for enzymatic fragmentation are used. Therefore, shorter fragmentation times may be required for these sample types to achieve the desired average fragment length. Alternatively, fragmentation can be carried out at a lower temperature to avoid over-fragmentation.